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Night is the time when we can give our body and brains the rest they need badly. Days are full of stress, work and wasting of energy so night hours serve us to restore our energy and strength. It is during night that we can forget about our troubles and worries so that in the morning know-how comes to our minds and we are ready to fight and reach our aims again. But sometimes stress and some health problems take away balmy night hours of sleep leaving us to suffer all nights through. And when the morning comes we face it irritated and frustrated – no energy for labor achievements, no desire to get involved in everyday activities. We wait for the evening to come in order to have rest but another night turns out to be sleepless – no rest for the brain, no use for health.

If your nights have become worse than any nightmare and you don’t remember when you managed to have full-time sleep last time you may have insomnia, a serious health problem which needs to be treated properly. Luckily enough modern medicine has a medication to offer you. This medication is called Ambien. Online purchasing of it will help you to fall and stay asleep as long as your body needs it.

In a randomized, double-blind, placebo-controlled, multicenter sleep laboratory study, Scharf et al. (1994b) evaluated the effectiveness of Zolpidem (IR) at doses of 10 mg and 15 mg in individuals with chronic insomnia (n=75, aged 21–60 years) over a 35-night period following a 4-night polysomnography (PSG) screening. The study also examined sleep stages, motor, and cognitive effects during the treatment period and a 3-night post-treatment phase.

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During the first week of treatment, 10 mg of Ambien significantly reduced latency to persistent sleep and improved sleep efficiency. These benefits were maintained throughout the 35 nights of use. No residual effects were observed with the 10 mg dose. Both the 10 mg and 15 mg doses preserved Stage 3–4 sleep. Additionally, no tolerance or rebound effects were noted, and there were no significant differences between the 10 mg Ambien group and the placebo group regarding sleep latency or efficiency during the post-treatment period.

For the 15 mg dose, similar improvements were observed. However, a significant reduction in REM sleep was noted at weeks 3 and 4 compared to placebo. Additionally, patients in the 15 mg group experienced worse sleep quality and longer wake time during sleep on the first night after discontinuing treatment, compared to placebo. Overall, the incidence of treatment-emergent adverse events in the Ambien groups was comparable to the placebo group.

The study concluded that Ambien 10 mg is safe and effective for treating chronic insomnia over 35 nights, providing consistent hypnotic benefits without altering sleep stages, causing tolerance, rebound effects, or negatively affecting psychomotor performance. The 15 mg dose offered no additional clinical benefits over the 10 mg dose.

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In a separate study by Lahmeyer et al. (1997), a double-blind, randomized, placebo-controlled, multicenter study compared the subjective hypnotic efficacy of Zolpidem (IR) 10 mg and 15 mg to placebo in 178 chronic insomnia patients aged 19–60 years (mean age 45 years) over 31 nights. The primary efficacy measures, derived from morning questionnaires (administered on days 1, 2, 3, and 7 of each week and a Clinical Global Impressions assessment on day 7 of week 4), included patients’ self-reported estimates of sleep latency and total sleep time.

Sleep Latency: Ambien IR 10 mg and 15 mg showed significantly greater reductions in self-reported subjective sleep latency compared to the placebo group during all treatment weeks, except at week 4 for the 15 mg group, where the change was not statistically significant. Sleep latency estimates remained stable over the 4-week treatment period, with no significant differences between the two Ambien groups.

Total Sleep Time: No notable differences were observed between the Ambien groups throughout the treatment period. All three groups (placebo, Zolpidem 10 mg, and Ambien 15 mg) reported significant improvements in total sleep time compared to baseline after 4 weeks of treatment. These increases were 41.5 minutes for placebo, 69.7 minutes for Ambien 10 mg, and 60.3 minutes for Ambien 15 mg.

Secondary Outcomes (Number of Awakenings, Sleep Quality, Next-Morning Sleepiness): The number of awakenings and sleep quality improved significantly in the early treatment phase for those taking Ambien. However, no significant differences in next-morning sleepiness were observed among the three groups, as assessed by a visual analogue scale. Over the study, all groups reported improved sleep quality, with numerical changes at week 4 being +9.3 points for placebo, +17.5 points for Zolpidem 10 mg, and +14.8 points for Ambien 15 mg.

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Clinical Global Impressions of Therapy: Both Ambien groups rated their improvement significantly higher than placebo on all measures, with no notable differences between the 10 mg and 15 mg doses.

Adverse Event Rates: Adverse event (AE) rates were 43% for placebo, 57% for Ambien IR 10 mg, and 70% for Ambien IR 15 mg, with the central and peripheral nervous systems being the most affected. Subjective sleep latency after treatment was generally equal to or shorter than baseline, except for a 27-minute increase on the first night following discontinuation in the Ambien 15 mg group (p < 0.10). Additionally, the 15 mg group exhibited shorter total sleep time on post-treatment nights and greater morning sleepiness compared to placebo on post-treatment days 1, 2, and 3, suggesting a potential perception of rebound insomnia.

Overall, patients reported no discernible difference in hypnotic efficacy between Ambien 10 mg and 15 mg. Increasing the dose above the recommended 10 mg daily did not enhance efficacy but resulted in a higher incidence of AEs.

Roth et al. (1995): This study compared the efficacy and next-morning psychomotor effects of Zolpidem IR 7.5 mg and 10 mg with placebo and evaluated dose-related effects of Ambien (5, 7.5, 10, 15, and 20 mg) in a single-night study with healthy volunteers (n=462, aged 21–60 years). Sleep latency decreased with higher doses, peaking at the 7.5–10 mg range, but increased slightly at 15 mg (mean 19 minutes) and 20 mg (mean 21 minutes). Sleep efficiency improved with the 10 mg dose but decreased slightly with the 15 mg and 20 mg doses.

While higher doses (15 mg and 20 mg) did not statistically improve efficacy, adverse events were more common at these doses. AEs were reported by 10.2% of participants overall, with rates increasing to 17.6% for the 15 mg dose (p = 0.069 vs. placebo) and 31.4% for the 20 mg dose (p = 0.001 vs. placebo).